Cholinergic Functioning in Stimulant Addiction
نویسندگان
چکیده
منابع مشابه
A psychomotor stimulant theory of addiction.
The theory is advanced that the common denominator of a wide range of addictive substances is their ability to cause psychomotor activation. This view is related to the theory that all positive reinforcers activate a common biological mechanism associated with approach behaviors and that this mechanism has as one of its components dopaminergic fibers that project up the medial forebrain bundle ...
متن کاملPsychomotor stimulant addiction: a neural systems perspective.
The reinforcing (rewarding) effects of psychomotor stimulants (cocaine and amphetamine) depend on the mesocorticolimbic dopamine system innervating the nucleus accumbens (Wise, 1981; for review, see Koob, 1992), perhaps especially the shell subregion (Bassareo and Di Chiara, 1997). Prominent theories of addiction are based on adaptations associated with both sensitization to and withdrawal from...
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Addiction to drugs is a major contemporary public health issue, characterized by maladaptive behavior to obtain and consume an increasing amount of drugs at the expense of the individual's health and social and personal life. We discovered abnormalities in fronto-striatal brain systems implicated in self-control in both stimulant-dependent individuals and their biological siblings who have no h...
متن کاملDopaminergic and cholinergic learning mechanisms in nicotine addiction
Nicotine addiction drives tobacco use by one billion people worldwide, causing nearly six million deaths a year. Nicotine binds to nicotinic acetylcholine receptors that are normally activated by the endogenous neurotransmitter acetylcholine. The widespread expression of nicotinic receptors throughout the nervous system accounts for the diverse physiological effects triggered by nicotine. A cru...
متن کاملPsychological problems and family functioning as risk factors in addiction.
OBJECTIVES The purpose of the present research was to determine the role of family functioning and psychological problems of drug addicts and non addicts by assessing the difference between the two groups. After detailed literature review it was hypothesized that scores on the variable of communication, affective expression and control among family members of addicts will be higher than non add...
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ژورنال
عنوان ژورنال: CNS Drugs
سال: 2009
ISSN: 1172-7047
DOI: 10.2165/11310920-000000000-00000